N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine
• CAS No.: 155880-04-9
• Molecular Formula: C₁₇H₂₆ClNO₃
• Molecular Weight: 327.851
• Mol file: 155880-04-9.mol

Synonyms:N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine

Chemical Property of N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine

There total 1 articles about N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,5-dichloropentane (628-76-2) + tert-butyl N-(benzyloxy)carbamate (79722-21-7) → N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine (155880-04-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 30 min, 2.) DMF, a.) 0 deg C, 20 min, b.) from 70 to 80 deg C, overnight;

DOI:10.1021/jm00036a005

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine (155880-04-9) → N-(5-chloropentyl)-O-benzylhydroxylamine (155880-05-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; 1.) 0 deg C, 20 min, 2.) RT, 15 min;

DOI:10.1021/jm00036a005

Reference yield:

N-(tert-butoxycarbonyl)-N-(5-chloropentyl)-O-benzylhydroxylamine (155880-04-9) → N-acetyl-N-(5-chloropentyl)-O-benzylhydroxylamine (155880-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / TFA / CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, 15 min

2: 96 percent / NaOH / H₂O; CH₂Cl₂ / 1.) 0 deg C, 20 min, 2.) RT, overnight

With sodium hydroxide; trifluoroacetic acid; In dichloromethane; water;

DOI:10.1021/jm00036a005

upstream raw materials:

1,5-dichloropentane

tert-butyl N-(benzyloxy)carbamate

Downstream raw materials:

N-acetyl-N'-(tert-butoxycarbonyl)-N,N'-bis(benzyloxy)-1,5-pentadiamine

N-(5-chloropentyl)-O-benzylhydroxylamine

N-acetyl-N-(5-chloropentyl)-O-benzylhydroxylamine