2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Base Information

Chemical Name:2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid
CAS No.:1383816-33-8
Molecular Formula:C₃₀H₂₈F₃N₃O₆S
Molecular Weight:615.63
Hs Code.:

2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Synonyms:2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

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Chemical Property of 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

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Technology Process of 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

There total 12 articles about 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383816-32-7
methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylate

: 1383816-33-8
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Guidance literature:: methyl 2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylate; With water; potassium hydroxide; In tetrahydrofuran; ethanol; at 60 ℃; for 2h;

With citric acid; In water;

Reference yield:

: (5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)-methanol

: 1383816-33-8
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / dichloromethane

1.2: 1 h

2.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

2.2: Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

5.1: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With 18-crown-6 ether; potassium tert-butylate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/acs.jmedchem.7b00907

Reference yield:

: 94651-33-9
2-(trifluoromethoxy)benzaldehyde

: 1383816-33-8
2-(3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide; hydroxylamine hydrochloride / water; ethanol / 1 h / 0 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 - 25 °C

3.1: potassium carbonate / tetrahydrofuran / 0.08 h / -10 °C

3.2: -5 - 35 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C / Inert atmosphere

5.1: triphenylphosphine / dichloromethane

5.2: 1 h

6.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 1 h / Inert atmosphere

6.2: Inert atmosphere

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: caesium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

9.1: potassium hydroxide / water; tetrahydrofuran; methanol / 1 h / 70 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; 18-crown-6 ether; hydroxylamine hydrochloride; potassium tert-butylate; potassium carbonate; caesium carbonate; triphenylphosphine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00907