3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Base Information

Chemical Name:3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide
CAS No.:949524-33-8
Molecular Formula:C₂₇H₂₂F₂N₂O₂
Molecular Weight:444.481
Hs Code.:

Synonyms:3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

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Chemical Property of 3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

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Technology Process of 3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

There total 10 articles about 3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 855248-38-3
3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid

: 949524-33-8
3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 80 °C

2: Et₃N / tetrahydrofuran / 12 h / 25 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 126209-33-4
3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 949524-33-8
3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 45 percent / POCl₃ / 1,2-dichloro-ethane / 3 h / 80 °C

2: 100 percent / NaOH / methanol / 2 h / 60 °C

3: SOCl₂ / 80 °C

4: Et₃N / tetrahydrofuran / 12 h / 25 °C

With sodium hydroxide; thionyl chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; 1: Vilsmeir-Haack reaction;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 126209-32-3
3,4-bis-(4-fluorophenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

: 949524-33-8
3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 62 percent / KOH / dimethylsulfoxide / 1.5 h / 25 °C

2: 45 percent / POCl₃ / 1,2-dichloro-ethane / 3 h / 80 °C

3: 100 percent / NaOH / methanol / 2 h / 60 °C

4: SOCl₂ / 80 °C

5: Et₃N / tetrahydrofuran / 12 h / 25 °C

With potassium hydroxide; sodium hydroxide; thionyl chloride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dimethyl sulfoxide; 1,2-dichloro-ethane; 2: Vilsmeir-Haack reaction;
DOI:10.1016/j.bmcl.2007.05.096