(+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride

Base Information

• Chemical Name: (+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride
• CAS No.: 137455-99-3
• Molecular Formula: C₃₁H₃₂ClN₃O₄*ClH
• Molecular Weight: 582.527
• Mol file: 137455-99-3.mol

Synonyms:(+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride

Chemical Property of (+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride

There total 3 articles about (+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(+/-)-2R*,11bS*-3'-(3-Chlorophenyl)-4'-imino-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one (136334-50-4) → (+/-)-2R*,11bS*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride (137455-99-3)

Guidance literature:

With hydrogenchloride; In ethanol; for 9h; Heating; or in methanol;

Reference yield:

(2R,11bS)-9,10-Dimethoxy-2-phenethylamino-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile (133308-73-3,136334-28-6) → (+/-)-2R*,11bS*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride (137455-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / triethylamine / benzene / 3 h / Ambient temperature; sonication

2: 65 percent / 35 percent aq. hydrochloric acid / ethanol / 9 h / Heating; or in methanol

With hydrogenchloride; triethylamine; In ethanol; benzene;

Reference yield:

m-chlorophenyl isocyanate (2909-38-8) → (+/-)-2R*,11bS*-3'-(3-Chlorophenyl)-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidine>-2',4'-dione hydrochloride (137455-99-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / triethylamine / benzene / 3 h / Ambient temperature; sonication

2: 65 percent / 35 percent aq. hydrochloric acid / ethanol / 9 h / Heating; or in methanol

With hydrogenchloride; triethylamine; In ethanol; benzene;

upstream raw materials:

(+/-)-2R^*,11bS^*-3'-(3-Chlorophenyl)-4'-imino-9,10-dimethoxy-1'-phenylethyl-1,3,4,6,7,11b-hexahydrospiroquinolizin-2,5'-imidazolidin>-2'-one

(2R,11bS)-9,10-Dimethoxy-2-phenethylamino-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline-2-carbonitrile

m-chlorophenyl isocyanate