(R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid

Base Information

• Chemical Name: (R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid
• CAS No.: 855588-12-4
• Molecular Formula: C₁₈H₂₈N₂O₃
• Molecular Weight: 320.432

Synonyms:(R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid

Chemical Property of (R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid

Chemical Property:

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Technology Process of (R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid

There total 1 articles about (R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2R)-2-{[2-(t-butylamino)-2-oxo-1-phenylethyl]amino}-4-methylpentanoate → (R)-2-[((R)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid + (R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid (855588-12-4)

Guidance literature:

With lithium hydroxide; In methanol; water; for 18h;

DOI:10.1021/jo0501137

Reference yield: 100.0%

(R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid (855588-12-4) + formyl acetic anhydride (2258-42-6) → (2R)-2-[[(1S)-2-(t-butylamino)-2-oxo-1-phenylethyl](formyl)amino]-4-methylpentanoic acid

Guidance literature:

With triethylamine; In dichloromethane; for 3h;

DOI:10.1021/jo0501137

Reference yield:

(R)-2-[((S)-tert-Butylcarbamoyl-phenyl-methyl)-amino]-4-methyl-pentanoic acid (855588-12-4) → methyl (2R)-2-[[(1S)-2-(t-butylamino)-2-oxo-1-phenylethyl](formyl)amino]-4-methylpentanoate

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / triethylamine / CH₂Cl₂ / 3 h

2: 80 percent / tetrahydrofuran; hexane / 2 h / 20 °C

With triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo0501137

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