2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

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Chemical Name:2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal
CAS No.:433292-98-9
Molecular Formula:C₁₆H₁₄ClN₅OS₂
Molecular Weight:391.905
Hs Code.:

2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1<i>H</i>-pyrazol-3-yl]-3-dimethylamino-propenal

Synonyms:2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

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Chemical Property of 2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

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Technology Process of 2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

There total 2 articles about 2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 100137-00-6
4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenyl-Δ²-pyrazolin-5-one

: 433292-98-9
2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.25h;

4-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)-3-methyl-1-phenyl-Δ²-pyrazolin-5-one; at 70 - 80 ℃; for 8h;

Reference yield:

: 57624-77-8
3-methyl-5-oxo-1-phenyl-Δ²-pyrazoline-4-thiocarbohydrazide

: 433292-98-9
2-[5-chloro-1-phenyl-4-(5-thioxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-1H-pyrazol-3-yl]-3-dimethylamino-propenal

Guidance literature:: Multi-step reaction with 2 steps

1.1: 41 percent / KOH / ethanol / 2 h / Heating

2.1: POCl₃ / 0.25 h / 0 °C

2.2: 96 percent / 8 h / 70 - 80 °C

With potassium hydroxide; trichlorophosphate; In ethanol; 2.1: Vilsmeier reaction;