(1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

Base Information

Chemical Name:(1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol
CAS No.:78822-86-3
Molecular Formula:C₁₈H₂₂O₃S
Molecular Weight:318.437
Hs Code.:

Synonyms:(1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

Chemical Property:

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Technology Process of (1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

There total 15 articles about (1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78837-34-0
(+/-)-threo-4-(Phenylthio)-3-methyl-2-butanol

: 78822-86-3
(1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: NaIO₄ / methanol; H₂O; tetrahydrofuran / 22 °C

2: Lithium Diisopropylamide / tetrahydrofuran / 0.02 h / -78 °C

3: 0.01 h

With sodium periodate; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo00333a045

Reference yield:

: 78822-84-1
1-<2(S)-methyl-3(S)-hydroxy>butylphenyl (R)-sulfoxide

: 78822-86-3
(1S,2R,3S,4S)-2-((R)-Benzenesulfinyl)-3-methyl-1-phenyl-pentane-1,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: Lithium Diisopropylamide / tetrahydrofuran / 0.02 h / -78 °C

2: 0.01 h

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00333a045

Reference yield:

: 100-68-5
methyl-phenyl-thioether

: 78822-86-3,78855-52-4,78855-53-5,78855-54-6,78855-55-7,78855-56-8,78855-60-4,78855-61-5,78855-62-6,78855-63-7,78855-64-8,78855-65-9,106454-19-7,106454-20-0,106454-21-1,106454-23-3,106454-24-4,106454-25-5,111002-03-0,111002-05-2
(+/-)-(1S^*, 2R^*, 3R^*, 4S^*)-3-methyl-1-phenyl-2-((S^*)-phenylsulfinyl)-1,4-pentanediol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuLi, HMPA / 1.) THF, -78 deg C; 2.) THF, -60 deg C

2: 95 percent / meta-peroxidate / methanol; H₂O; tetrahydrofuran / 24 h / 22 °C

3: 1.) lithium diisopropylamide / 1.) THF, - 78 deg C, 1 min.; 2.) THF, -78 deg C, 1 min.

With N,N,N,N,N,N-hexamethylphosphoric triamide; meta-peroxidate; tert.-butyl lithium; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4020(01)90591-5