3,3-dimethyl-2-p-tolylcyclopentenone

Base Information

• Chemical Name: 3,3-dimethyl-2-p-tolylcyclopentenone
• CAS No.: 55873-31-9
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 202.296
• Mol file: 55873-31-9.mol

Synonyms:3,3-dimethyl-2-p-tolylcyclopentenone

Chemical Property of 3,3-dimethyl-2-p-tolylcyclopentenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-2-p-tolylcyclopentenone

There total 14 articles about 3,3-dimethyl-2-p-tolylcyclopentenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4,4-Dimethyl-2-oxo-3-p-tolyl-cyclopentanecarboxylic acid methyl ester (119927-16-1) → 3,3-dimethyl-2-p-tolylcyclopentenone (55873-31-9)

Guidance literature:

With water; sodium chloride; In dimethyl sulfoxide; at 150 ℃; for 30h;

Reference yield: 65.2%

3-methyl-2-(4-methylphenyl)-2-cyclopenten-1-one (70855-14-0) + lithium dimethylcuprate (15681-48-8) → 3,3-dimethyl-2-p-tolylcyclopentenone (55873-31-9)

Guidance literature:

With dimethylsulfide; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

4,4-Dimethyl-3-p-tolyl-cyclohexanone (119927-13-8) → 3,3-dimethyl-2-p-tolylcyclopentenone (55873-31-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / 1.) NaH, 2.) Et₃N / 1,2-dimethoxy-ethane / 1.) reflux, 24 h, 2.) 0 deg C, 30 min

2: 1.) O₃, dimethyl sulfide, 2.) Jone's reagent / 1.) CH₂Cl₂, -50 deg C, 2.) acetone, 0 deg C, 30 min

3: diethyl ether / 0 °C

4: 62 percent / t-BuOK / tetrahydrofuran / 5 h / Heating

5: 88 percent / NaCl, H₂O / dimethylsulfoxide / 30 h / 150 °C

With dimethylsulfide; Jones reagent; potassium tert-butylate; water; sodium hydride; ozone; triethylamine; sodium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dimethyl sulfoxide;

upstream raw materials:

3-methyl-2-(4-methylphenyl)-2-cyclopenten-1-one

lithium dimethylcuprate

4,4-Dimethyl-2-oxo-3-p-tolyl-cyclopentanecarboxylic acid methyl ester

5,5-dimethyl-1-p-tolylcyclopentene

Downstream raw materials:

5-cuparenone