(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

Base Information

Chemical Name:(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate
CAS No.:785790-01-4
Molecular Formula:C₁₈H₂₅NO₄
Molecular Weight:319.401
Hs Code.:

Synonyms:(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

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Chemical Property of (3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

Chemical Property:

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Technology Process of (3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

There total 2 articles about (3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 79-22-1
methyl chloroformate

: 624739-11-3
(3R,5E,αR)-methyl 3-(N-[α-methylbenzyl]amino)-hept-5-enoate

: 785790-01-4
(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

Guidance literature:: With potassium carbonate; In acetone; for 24h; Heating;
DOI:10.1039/b404962d

Reference yield:

: 126275-19-2
(R)-N-allyl (1-phenylethyl)amine

: 785790-01-4
(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-Bu₃P; HBF₄ / Pd₂(dba)3 / CHCl₃; diethyl ether / 5 h / 80 °C

1.2: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.3: 31.1 g / tetrahydrofuran; hexane / 1 h / -78 °C

2.1: 97 percent / RhCl(PPh₃)3 / acetonitrile; H₂O / 2 h / Heating

3.1: 84 percent / K₂CO₃ / acetone / 24 h / Heating

With tetrafluoroboric acid; tributylphosphine; potassium carbonate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; RhCl(PPh₃)3; In diethyl ether; chloroform; water; acetone; acetonitrile;
DOI:10.1039/b404962d

Reference yield:

: 785790-01-4
(3R,5E,αR)-methyl 3-(N-methoxycarbonyl-N-α-methylbenzylamino)hept-5-enoate

: (4R,6S,1'R,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-iodoethyl)-1,3-oxazin-2-one

: 624739-02-2
(4R,6R,1'S,αR)-3-(α-methylbenzyl)-4-(methoxycarbonylmethyl)-6-(1'-iodoethyl)-1,3-oxazinan-2-one

Guidance literature:: With iodine; potassium iodide; In dichloromethane; at 0 - 20 ℃; for 77h; Title compound not separated from byproducts;
DOI:10.1039/b404962d