2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

Base Information

Chemical Name:2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide
CAS No.:259670-58-1
Molecular Formula:C₁₉H₂₆N₂O₂
Molecular Weight:314.428
Hs Code.:

Synonyms:2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

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Chemical Property of 2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

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Technology Process of 2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

There total 7 articles about 2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 61-54-1
tryptamine

: 259670-57-0
(1S,6S)-4-oxabicyclo[4.4.0]decan-3-one

: 259670-58-1
2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

Guidance literature:: In xylene; for 3h; Heating;
DOI:10.3987/com-99-s20

Reference yield:

: 5689-04-3
cis-hexahydro-1H-inden-2(3H)-one

: 259670-58-1
2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / BF₃*OEt₂ / CH₂Cl₂ / 20 °C

2: ozone / methanol; CH₂Cl₂ / -78 °C

3: 133 mg / NaBH₄ / methanol; CH₂Cl₂ / -78 - 0 °C

4: xylene / 3 h / 100 °C

With sodium tetrahydroborate; boron trifluoride diethyl etherate; ozone; In methanol; dichloromethane; xylene;
DOI:10.1016/j.tet.2004.01.015

Reference yield:

: (2-Formyl-cyclohexyl)-acetic acid (1S,2S)-2-hydroxy-cycloheptyl ester

: 259670-58-1
2-[(1S,2S)-2-(hydroxymethyl)cyclohexyl]-N-[2-(1H-indol-3-yl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 133 mg / NaBH₄ / methanol; CH₂Cl₂ / -78 - 0 °C

2: xylene / 3 h / 100 °C

With sodium tetrahydroborate; In methanol; dichloromethane; xylene;
DOI:10.1016/j.tet.2004.01.015