(+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione

Base Information

• Chemical Name: (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione
• CAS No.: 171232-73-8
• Molecular Formula: C₁₉H₁₈N₂O₂S
• Molecular Weight: 338.43
• Mol file: 171232-73-8.mol

Synonyms:(+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione

Chemical Property of (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione

There total 5 articles about (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione (171232-73-8)

Guidance literature:

Reference yield: 87.0%

(4S,5R)-1,3-dibenzyl-5-hydroxymethyl-2-oxoimidazolidine-4-carboxylic acid lactone (87585-00-0) → (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione (171232-73-8)

Guidance literature:

With potassium thioacetate; In N,N-dimethyl-formamide; at 150 ℃;

DOI:10.1016/S0040-4039(99)01864-X

Reference yield:

(+)-cis-1,3-dibenzyl-hexahydro-1H-thieno[3,4-d]imidazole-2,4-dione (21035-72-3) → (3aS,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione (28092-52-6) + (+)-cis-1,3-dibenzylhexahydro-1H-thieno-[3,4-d]imidazole-2,4-dione (171232-73-8)

Guidance literature:

With chiral stationary phase derived from aminated silica gel, L-2-(p-toluenesulfonamido)-3-phenylpropionyl chloride and dendrimer; In methanol; water; at 25 ℃; Resolution of racemate;

DOI:10.1002/chir.20708

upstream raw materials:

(4S,5R)-1,3-dibenzyl-5-hydroxymethyl-2-oxoimidazolidine-4-carboxylic acid lactone

(+)-cis-1,3-dibenzyl-hexahydro-1H-thieno[3,4-d]imidazole-2,4-dione