3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

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Chemical Name:3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid
CAS No.:632624-20-5
Molecular Formula:C₂₅H₁₇Br₂ClFNO₃
Molecular Weight:593.674
Hs Code.:

Synonyms:3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

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Chemical Property of 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

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Technology Process of 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

There total 4 articles about 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 632627-48-6
1-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-pentane-1,4-dione

: 42237-85-4
3-amino-5-bromobenzoic acid

: 632624-20-5
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; at 160 ℃; for 0.166667h; Microwave irradiation;

Reference yield:

: 632627-47-5
5-chloro-2-(4-bromo-2-fluorobenzyloxy)-benzaldehyde

: 632624-20-5
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 7 h / Heating / reflux

2: toluene-4-sulfonic acid / acetonitrile / 0.17 h / 160 °C / Microwave irradiation

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; triethylamine; In ethanol; acetonitrile;

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 632624-20-5
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-bromobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3 h / 60 °C

2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 7 h / Heating / reflux

3: toluene-4-sulfonic acid / acetonitrile / 0.17 h / 160 °C / Microwave irradiation

With 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In DMF (N,N-dimethyl-formamide); ethanol; acetonitrile;