tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate
CAS No.:951127-24-5
Molecular Formula:C₁₆H₁₈F₃NO₄
Molecular Weight:345.318
Hs Code.:
Mol file:951127-24-5.mol

Synonyms:tert-butyl ((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

Suppliers and Price of tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

ChemScene
tert-Butyl((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate
1g
$ 2469.00

ChemScene
tert-Butyl((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate
500mg
$ 1507.00

ChemScene
tert-Butyl((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate
100mg
$ 443.00

Total 5 raw suppliers

Chemical Property of tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate

There total 17 articles about tert-butyl (2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: tert-butyl ((2R,3S)-5-hydroxy-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

: 951127-24-5
tert-butyl ((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: With phthalic acid dimethyl ester; In dichloromethane; at 0 - 30 ℃; for 4h;

Reference yield:

: 951127-23-4
tert-butyl [(2R,3S)-5-hydroxy-5-(hydroxymethyl)-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl]carbamate

: 951127-24-5
tert-butyl ((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; for 3h;

Reference yield:

: 88419-56-1
2,4,5-trifluorobenzoyl chloride

: 951127-24-5
tert-butyl ((2R,3S)-5-oxo-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; hexane; mineral oil / 2.5 h / 20 °C / Inert atmosphere

2.2: 0 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2.5 h / 60 °C

4.1: sodium tetrahydroborate / isopropyl alcohol; chloroform / 0.5 h / 20 °C

4.2: 1.75 h

5.1: ChiralCel OD / isopropyl alcohol; n-heptane / Resolution of racemate

6.1: hydrogenchloride; zinc / ethanol / 1 h

7.1: dichloromethane / 2.5 h / 20 °C

8.1: osmium(VIII) oxide / water; tert-butyl alcohol; acetone / 0.17 h / 20 °C

8.2: 48 h

9.1: sodium periodate / water; tetrahydrofuran / 3 h

With hydrogenchloride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium hydride; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; ethanol; hexane; n-heptane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; mineral oil; tert-butyl alcohol;