C₃₅H₆₀O₈Si₂

Base Information

Chemical Name:C₃₅H₆₀O₈Si₂
CAS No.:814920-05-3
Molecular Formula:C₃₅H₆₀O₈Si₂
Molecular Weight:665.028
Hs Code.:

C<sub>35</sub>H<sub>60</sub>O<sub>8</sub>Si<sub>2</sub>

Synonyms:C₃₅H₆₀O₈Si₂

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Chemical Property of C₃₅H₆₀O₈Si₂

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Technology Process of C₃₅H₆₀O₈Si₂

There total 18 articles about C₃₅H₆₀O₈Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 814920-26-8
(S)-2-[(1R,2S,6R,7S,8R,9R)-9-Benzyloxymethyl-4,4-dimethyl-10-oxo-8-(2-trimethylsilanyl-ethoxymethoxymethyl)-3,5-dioxa-tricyclo[5.2.2.0^2,6]undec-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde

: 814920-05-3
C₃₅H₆₀O₈Si₂

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; In tetrahydrofuran; at -40 - 0 ℃; for 0.75h;
DOI:10.1021/jo048681u

Reference yield:

: 312923-90-3
(1S,3R,7R,8S,9R,10S,11S)-9-Benzyloxymethyl-10-hydroxymethyl-11-methyl-7-trimethylsilanyloxy-4-oxa-tricyclo[5.3.1.0^3,8]undecan-5-one

: 814920-05-3
C₃₅H₆₀O₈Si₂

Guidance literature:: Multi-step reaction with 16 steps

1.1: 29 percent / diacetoxyiodobenzene; iodine / CH₂Cl₂ / 0.83 h / 0 °C / Irradiation

2.1: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / 20 °C

3.1: O₃ / CH₂Cl₂ / 0.25 h / -78 °C

3.2: 83 percent / PPh₃ / CH₂Cl₂ / -78 - 20 °C

4.1: Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

5.1: tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

6.1: 2.25 g / PPTS / acetone / 14 h / 20 °C

7.1: LiHMDS; HMPA / tetrahydrofuran / 1.5 h / -78 °C

7.2: 86 percent / tetrahydrofuran / 0.92 h / -78 - -40 °C

8.1: O₃ / CH₂Cl₂ / 0.08 h / -78 °C

8.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

9.1: 197 mg / NaBH₄ / CH₂Cl₂; methanol / 0.08 h / 20 °C

10.1: 97 percent / n-Bu₃P / tetrahydrofuran / 1.67 h / -78 - 20 °C

11.1: 252 mg / H₂O₂ / tetrahydrofuran / 12 h / 20 °C

12.1: 335 mg / LiAlH₄ / dioxane / 0.02 h / Heating

13.1: 345 mg / Et₃N; DMAP / CH₂Cl₂ / 1.17 h / 20 °C

14.1: 93 percent / 4-methylmorpholine N-oxide / TPAP / acetonitrile / 1 h / 20 °C

15.1: O₃ / CH₂Cl₂ / 0.67 h / -78 °C

15.2: 88 percent / triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

16.1: 86 percent / SmI₂; HMPA / tetrahydrofuran / 0.75 h / -40 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; samarium diiodide; zinc(II) tetrahydroborate; tributylphosphine; [bis(acetoxy)iodo]benzene; tetrabutyl ammonium fluoride; dihydrogen peroxide; iodine; pyridinium p-toluenesulfonate; ozone; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrapropylammonium perruthennate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; acetone; acetonitrile; 11.1: Grieco olefination;
DOI:10.1021/jo048681u

Reference yield:

: (1S,3R,7S,8S,9R,10R,11R)-9-Benzyloxymethyl-7,11-dihydroxy-10-(2-trimethylsilanyl-ethoxymethoxymethyl)-4-oxa-tricyclo[5.3.1.0^3,8]undecan-5-one

: 814920-05-3
C₃₅H₆₀O₈Si₂

Guidance literature:: Multi-step reaction with 11 steps

1.1: 2.25 g / PPTS / acetone / 14 h / 20 °C

2.1: LiHMDS; HMPA / tetrahydrofuran / 1.5 h / -78 °C

2.2: 86 percent / tetrahydrofuran / 0.92 h / -78 - -40 °C

3.1: O₃ / CH₂Cl₂ / 0.08 h / -78 °C

3.2: triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

4.1: 197 mg / NaBH₄ / CH₂Cl₂; methanol / 0.08 h / 20 °C

5.1: 97 percent / n-Bu₃P / tetrahydrofuran / 1.67 h / -78 - 20 °C

6.1: 252 mg / H₂O₂ / tetrahydrofuran / 12 h / 20 °C

7.1: 335 mg / LiAlH₄ / dioxane / 0.02 h / Heating

8.1: 345 mg / Et₃N; DMAP / CH₂Cl₂ / 1.17 h / 20 °C

9.1: 93 percent / 4-methylmorpholine N-oxide / TPAP / acetonitrile / 1 h / 20 °C

10.1: O₃ / CH₂Cl₂ / 0.67 h / -78 °C

10.2: 88 percent / triphenylphosphine / CH₂Cl₂ / -78 - 20 °C

11.1: 86 percent / SmI₂; HMPA / tetrahydrofuran / 0.75 h / -40 - 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; samarium diiodide; tributylphosphine; dihydrogen peroxide; pyridinium p-toluenesulfonate; ozone; 4-methylmorpholine N-oxide; triethylamine; lithium hexamethyldisilazane; tetrapropylammonium perruthennate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone; acetonitrile; 6.1: Grieco olefination;
DOI:10.1021/jo048681u