(-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane

Base Information

• Chemical Name: (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane
• CAS No.: 219584-44-8
• Molecular Formula: C₁₄H₂₂O₂Si
• Molecular Weight: 250.413
• Mol file: 219584-44-8.mol

Synonyms:(-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane

Chemical Property of (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane

There total 3 articles about (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trimethylsilyl trifluoromethanesulfonate (27607-77-8) + (-)-(S)-3-(phenylmethoxy)-2-butanone (97203-22-0,98168-70-8) → (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane (219584-44-8)

Guidance literature:

With triethylamine; In benzene; at 0 - 20 ℃;

DOI:10.1021/ja001023g

Reference yield: 96.0%

t-butyldimethylsiyl triflate (69739-34-0) + (-)-(S)-3-(phenylmethoxy)-2-butanone (97203-22-0,98168-70-8) → (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane (219584-44-8)

Guidance literature:

With triethylamine; In benzene; at 0 - 20 ℃;

DOI:10.1021/jo981739i

Reference yield:

methyl (S)-2-(benzyloxy)propanoate (77287-11-7) → (-)-(S)-trimethyl-<<1-<(phenylmethoxy)ethyl>ethenyl>oxy>silane (219584-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methyllithium / diethyl ether; tetrahydrofuran / -107 °C

1.2: 93 percent / tetrahydrofuran; diethyl ether / -105 - 20 °C

2.1: 96 percent / Et₃N / benzene / 0 - 20 °C

With methyllithium; triethylamine; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1021/ja001023g

upstream raw materials:

t-butyldimethylsiyl triflate

(-)-(S)-3-(phenylmethoxy)-2-butanone

trimethylsilyl trifluoromethanesulfonate

methyl (S)-2-(benzyloxy)propanoate

Downstream raw materials:

(+)-(R)-1-cyclohexyl-1-hydroxy-3-heptanone

(-)-(S)-1-cyclohexyl-1-hydroxy-3-heptanone