αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

Base Information

Chemical Name:αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester
CAS No.:549531-95-5
Molecular Formula:C₁₄H₁₈BrNO₃
Molecular Weight:328.206
Hs Code.:

Synonyms:αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

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Chemical Property of αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

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Technology Process of αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

There total 10 articles about αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,5R)-1-(tert-butoxycarbonyl)-5-[(S)-methoxycarbonyl(4-bromophenyl)methyl]-2-[tert-butyldiphenylsilyloxymethyl]pyrrolidine

: 549531-95-5
αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 5h;
DOI:10.1021/ja0290072

Reference yield:

: 264881-99-4
methyl 2-(4-bromophenyl)-2-diazoacetate

: 549531-95-5
αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Rh₂(S-DOSP)4 / various solvent(s) / 50 °C

2: NaOH / methanol

3: HCl / dioxane

With hydrogenchloride; sodium hydroxide; Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; In 1,4-dioxane; methanol;
DOI:10.1021/ja0290072

Reference yield:

: 59378-81-3,69610-40-8,83435-58-9
1-(tert-butoxycarbonyl)prolin-2R-ol

: 549531-95-5
αS-(4-bromophenyl)(5R-hydroxymethyl-pyrrolidin-2R-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / pyridine; dimethylaminopyridine / CH₂Cl₂ / 2 h / 23 °C

2: 92 percent / Rh₂(S-DOSP)4 / various solvent(s) / 50 °C

3: NaOH / methanol

4: HCl / dioxane

With pyridine; hydrogenchloride; dmap; sodium hydroxide; Rh₂[(N-(4-dodecylphenyl)sulfonyl)-(S)-prolinate]4; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1021/ja0290072