thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

Base Information

Chemical Name:thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate
CAS No.:1256039-27-6
Molecular Formula:C₂₄H₂₅FN₄O₂S
Molecular Weight:452.553
Hs Code.:

Synonyms:thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

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Chemical Property of thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

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Technology Process of thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

There total 6 articles about thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256039-26-5
thiazol-4-ylmethyl {[(3aR,5s,6aS)-2-(5-bromopyrid-2-yl)octahydrocyclopenta[c]pyrrol-5-yl]methyl}carbamate

: 1765-93-1
4-fluoroboronic acid

: 1256039-27-6
thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 75 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 912563-48-5
tert-butyl (3aR,5r,6aS)-5-hydroxy-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

: 1256039-27-6
thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: dimethyl sulfoxide / 1 h / 80 °C

2: hydrogen; sodium hydroxide / Raney nickel / ethanol / 6 h / 20 °C / 3000.3 Torr

3: N-ethyl-N,N-diisopropylamine / dmap / 1,2-dichloro-ethane / 1.5 h / 70 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 100 °C / Sealed tube

6: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 2.5 h / 75 °C / Inert atmosphere

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1256039-46-9
tert-butyl (3aR,5s,6aS)-5-({[(1,3-thiazol-4-ylmethoxy)-carbonyl]amino}methyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

: 1256039-27-6
thiazol-4-ylmethyl ({(3aR,5s,6aS)-2-[5-(4-fluorophenyl)-pyrid-2-yl]octahydrocyclopenta[c]pyrrol-5-yl}methyl)-carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 6 h / 100 °C / Sealed tube

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 2.5 h / 75 °C / Inert atmosphere

With caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; water; acetonitrile;