N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine

Base Information

• Chemical Name: N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine
• CAS No.: 1421045-12-6
• Molecular Formula: C₂₅H₃₀N₆O₂
• Molecular Weight: 446.552

Synonyms:N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine

Chemical Property of N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine

Chemical Property:

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Technology Process of N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine

There total 5 articles about N⁶-mesityl-3-nitro-N²-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N6-mesityl-3-nitro-N2-(piperidin-4-yl)pyridine-2,6-diamine (1421045-23-9) + 4-picolylchloride hydrochloride (1822-51-1) → N6-mesityl-3-nitro-N2-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine (1421045-12-6)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃;

DOI:10.1002/cmdc.201300130

Reference yield:

(6-chloro-3-nitropyridin-2-yl)-(1-Boc-piperidin-4-yl)amine (400801-28-7) → N6-mesityl-3-nitro-N2-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine (1421045-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 130 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: potassium carbonate / acetone / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1002/cmdc.201300130

Reference yield:

N6-mesityl-N2-(1-Boc-piperidin-4-yl)-3-nitropyridine-2,6-diamine (1421045-22-8) → N6-mesityl-3-nitro-N2-(1-(pyridin-4-ylmethyl)piperidin-4-yl)pyridine-2,6-diamine (1421045-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: potassium carbonate / acetone / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetone;

DOI:10.1002/cmdc.201300130

upstream raw materials:

(6-chloro-3-nitropyridin-2-yl)-(1-Boc-piperidin-4-yl)amine

N⁶-mesityl-N²-(1-Boc-piperidin-4-yl)-3-nitropyridine-2,6-diamine

N⁶-mesityl-3-nitro-N²-(piperidin-4-yl)pyridine-2,6-diamine

4-picolylchloride hydrochloride

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