4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Base Information

Chemical Name:4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate
CAS No.:1255925-44-0
Molecular Formula:C₁₇H₁₄Cl₂F₃NO₃S
Molecular Weight:440.27
Hs Code.:

Synonyms:4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

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Chemical Property of 4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

There total 4 articles about 4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 34041-52-6
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-hydroxy-2-methylisoquinoline

: 1255925-44-0
4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at -78 - 0 ℃; for 1h;

Reference yield:

: 802051-24-7
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanol

: 1255925-44-0
4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C

1.2: pH ~ 9

2.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate

3.1: hydrogen bromide / water; acetic acid / 8 h / Reflux

4.1: pyridine / dichloromethane / 1 h / -78 - 0 °C

With pyridine; sulfuric acid; hydrogen bromide; In dichloromethane; water; acetic acid; diethylamine; isopropyl alcohol;

Reference yield:

: 1254941-88-2
1-(3,4-dichlorophenyl)-2-((3-methoxybenzyl)(methyl)amino)ethanone

: 1255925-44-0
4-(3,4-dichlorophenyl)-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2.1: sulfuric acid / dichloromethane; water / 28 h / 0 °C

2.2: pH ~ 9

3.1: Chiralpak AD column / diethylamine; isopropyl alcohol / Resolution of racemate

4.1: hydrogen bromide / water; acetic acid / 8 h / Reflux

5.1: pyridine / dichloromethane / 1 h / -78 - 0 °C

With pyridine; sodium tetrahydroborate; sulfuric acid; hydrogen bromide; In methanol; dichloromethane; water; acetic acid; diethylamine; isopropyl alcohol;