(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Base Information

Chemical Name:(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal
CAS No.:457630-88-5
Molecular Formula:C₃₆H₅₂O₆Si₂
Molecular Weight:636.976
Hs Code.:

Synonyms:(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Suppliers and Price of (2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

There total 14 articles about (2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 457630-87-4
(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-yn-1-ol

: 457630-88-5
(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Guidance literature:: With phthalic acid dimethyl ester; In pyridine; at 20 ℃; for 1.5h;
DOI:10.1021/ol0262284

Reference yield:

: 488-82-4
D-Arabitol

: 457630-88-5
(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Guidance literature:: Multi-step reaction with 13 steps

1.1: 90 percent / CSA / dimethylformamide / 38 °C

2.1: SO₃*pyridine; i-Pr₂NEt / dimethylsulfoxide / 1 h / 20 °C

3.1: NaHMDS / 0 - 20 °C

3.2: 4 h / 0 °C

4.1: CSA; H₂O / methanol; CH₂Cl₂ / 7 h / 40 °C

5.1: imidazole; DMAP / dimethylformamide; CH₂Cl₂ / 12 h / 20 °C

6.1: 38 percent / CSA / 48 h / 40 °C

7.1: TBAF / tetrahydrofuran / 1.5 h

8.1: pyridine / CH₂Cl₂ / 0 - 20 °C

9.1: 98 percent / DMP; pyridine / CH₂Cl₂

10.1: t-BuLi; MgBr₂*Et₂O / benzene / 25 h / -78 - 20 °C

10.2: 70 percent / MgBr₂*Et₂O / CH₂Cl₂; benzene / 0.75 h / 0 °C

11.1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

12.1: 88 percent / super-hydride / tetrahydrofuran / 0.58 h / 0 °C

13.1: 98 percent / DMP / pyridine / 1.5 h / 20 °C

With pyridine; 1H-imidazole; 2,6-dimethylpyridine; dmap; pyridine-SO₃ complex; phthalic acid dimethyl ester; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; tert.-butyl lithium; sodium hexamethyldisilazane; lithium triethylborohydride; N-ethyl-N,N-diisopropylamine; magnesium bromide; In tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene; 3.1: Wittig reaction / 9.1: Dess-Martin oxidation;
DOI:10.1021/ol0262284

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 457630-88-5
(2S,4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-2,4-bis-(4-methoxy-benzyloxy)-3,6-dimethylene-9-trimethylsilanyl-non-8-ynal

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

2: 88 percent / super-hydride / tetrahydrofuran / 0.58 h / 0 °C

3: 98 percent / DMP / pyridine / 1.5 h / 20 °C

With 2,6-dimethylpyridine; phthalic acid dimethyl ester; lithium triethylborohydride; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1021/ol0262284