ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate
CAS No.:1197054-07-1
Molecular Formula:C₂₀H₁₄Cl₂F₄N₂O₂
Molecular Weight:461.243
Hs Code.:

Synonyms:ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Suppliers and Price of ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

There total 4 articles about ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.4%

: C₂₀H₁₅ClF₄N₂O₃

: 1197054-07-1
ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: With thionyl chloride; In dichloromethane; for 8h; Reflux;

Reference yield:

: 96606-37-0,103498-69-7
2,4,6-trifluorobenzonitrile

: 1197054-07-1
ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; potassium carbonate / dimethyl sulfoxide / 20 °C

2: acetic acid / 0.5 h / 20 °C

3: 5%-palladium/activated carbon; hydrogen / 2.5 h / 1520.1 Torr

4: sodium acetate / ethanol / 20 h / Reflux

With 5%-palladium/activated carbon; hydroxylamine hydrochloride; hydrogen; sodium acetate; potassium carbonate; acetic acid; In ethanol; dimethyl sulfoxide; 4: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.bmcl.2014.07.032

Reference yield:

: 1207204-82-7
2,4,6-trifluoro-N'-hydroxybenzimidamide

: 1197054-07-1
ethyl 2-(2,4,6-trifluorophenyl)-4-(2-chloro-4-fluorophenyl)-6-(chloromethyl)-1,4-dihydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 0.5 h / 20 °C

2: 5%-palladium/activated carbon; hydrogen / 2.5 h / 1520.1 Torr

3: sodium acetate / ethanol / 20 h / Reflux

With 5%-palladium/activated carbon; hydrogen; sodium acetate; acetic acid; In ethanol; 3: |Biginelli Pyrimidone Synthesis;
DOI:10.1016/j.bmcl.2014.07.032