1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

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Chemical Name:1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene
CAS No.:896104-56-6
Molecular Formula:C₅₃H₈₀O₄Si₂
Molecular Weight:837.387
Hs Code.:

1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

Synonyms:1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

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Chemical Property of 1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

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Technology Process of 1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

There total 17 articles about 1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 896104-77-1
(Z)-4-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-2-{(4S,5S)-5-[3-(4-methoxy-benzyloxy)-propyl]-4-methyl-cyclopent-1-enyl}-but-2-en-1-ol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 896104-56-6
1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jo0604585

Reference yield:

: 896104-51-1
(E)-(2S,3S)-2-[3-(4-Methoxy-benzyloxy)-propyl]-3-methyl-hex-4-enoic acid

: 896104-56-6
1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 80 percent / MsCl; Et₃N / tetrahydrofuran / 1 h / 0 °C

2.1: 82 percent / tetrahydrofuran / 20 °C

3.1: Grubbs catalyst / CH₂Cl₂ / Heating

4.1: H₂ / Pd/C / ethyl acetate / 2 h

5.1: LHMDS / toluene / 1 h / -78 °C

5.2: tetrahydrofuran / 4 h / -78 - 20 °C

6.1: HSnBu₃; Pd(PPh₃)4 / tetrahydrofuran / 2 h

6.2: 1.18 percent / Pd(PPh₃)4; LiCl; CuCl / dimethylsulfoxide / 37 h / 60 °C

7.1: 87 percent / DIBAL-H / CH₂Cl₂ / -78 - 20 °C

8.1: 93 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 6.2: Stille coupling;
DOI:10.1021/jo0604585

Reference yield:

: 896104-74-8
(2S,3S,4E)-N-methoxy-2-{3-[(4-methoxybenzyl)oxy]propyl}-N,3-dimethylhex-4-enamide

: 896104-56-6
1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 82 percent / tetrahydrofuran / 20 °C

2.1: Grubbs catalyst / CH₂Cl₂ / Heating

3.1: H₂ / Pd/C / ethyl acetate / 2 h

4.1: LHMDS / toluene / 1 h / -78 °C

4.2: tetrahydrofuran / 4 h / -78 - 20 °C

5.1: HSnBu₃; Pd(PPh₃)4 / tetrahydrofuran / 2 h

5.2: 1.18 percent / Pd(PPh₃)4; LiCl; CuCl / dimethylsulfoxide / 37 h / 60 °C

6.1: 87 percent / DIBAL-H / CH₂Cl₂ / -78 - 20 °C

7.1: 93 percent / imidazole / dimethylformamide / 18 h / 20 °C

With 1H-imidazole; Grubbs catalyst first generation; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; tri-n-butyl-tin hydride; diisobutylaluminium hydride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 5.2: Stille coupling;
DOI:10.1021/jo0604585