N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester

Base Information

• Chemical Name: N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester
• CAS No.: 913563-77-6
• Molecular Formula: C₁₆H₁₇F₄NO₂
• Molecular Weight: 331.31
• Mol file: 913563-77-6.mol

Synonyms:N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester

Chemical Property of N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester

There total 2 articles about N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

methyl 1-(4-fluorophenyl)but-3-enylcarbamate (913563-72-1) + toluene-4-sulfonic acid 2-trifluoromethylallyl ester (693826-80-1) → N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester (913563-77-6)

Guidance literature:

methyl 1-(4-fluorophenyl)but-3-enylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

toluene-4-sulfonic acid 2-trifluoromethylallyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1021/jo060893z

Reference yield:

4-fluorobenzaldehyde (459-57-4) → N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester (913563-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 50 percent / BF₃*OEt₂ / CH₂Cl₂ / 3 h / 20 °C

2.1: NaH / dimethylformamide / 0.25 h / 20 °C

2.2: 56 percent / dimethylformamide / 12 h / 20 °C

With boron trifluoride diethyl etherate; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo060893z

Reference yield: 80.0%

N-[1-(4-fluorophenyl)but-3-enyl]-N-(2-trifluoromethylallyl)carbamic acid methyl ester (913563-77-6) → 2-(4-fluorophenyl)-5-trifluoromethyl-3,6-dihydro-2H-pyridine-1-carboxylic acid methyl ester

Guidance literature:

tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In toluene; at 80 ℃; for 1h;

DOI:10.1021/jo060893z

upstream raw materials:

methyl 1-(4-fluorophenyl)but-3-enylcarbamate

toluene-4-sulfonic acid 2-trifluoromethylallyl ester

4-fluorobenzaldehyde