tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate
CAS No.:1449428-78-7
Molecular Formula:C₃₁H₃₉Cl₂N₅O₆S₂
Molecular Weight:712.719
Hs Code.:

tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

There total 9 articles about tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1449428-77-6
ClH*C₁₉H₁₈Cl₂N₄O₄S₂

: 169457-73-2
tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate

: 1449428-78-7
tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: ClH*C₁₉H₁₈Cl₂N₄O₄S₂; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

tert-butyl 4-(2-bromoethyl)piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 2,4-dichloro-5-(morpholinosulfonyl)benzoyl chloride

: 1449428-78-7
tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 20 °C

2.1: dichloromethane / 2 h / 20 °C / Acidic conditions

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.013

Reference yield:

: 150986-83-7
2-amino-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyridine-6-carboxylic acid tert-butyl ester

: 1449428-78-7
tert-butyl 4-(2-(3-cyano-2-(2,4-dichloro-5-(morpholinosulfonyl)benzamido)-4,5-dihydrothieno[2,3-c]pyridin-6(7H)-yl)ethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / dichloromethane / 20 °C

2.1: dichloromethane / 2 h / 20 °C / Acidic conditions

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 20 °C

With pyridine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.05.013