1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

Base Information

Chemical Name:1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide
CAS No.:1312572-64-7
Molecular Formula:C₂₀H₁₉F₃N₆OS
Molecular Weight:448.472
Hs Code.:

Synonyms:1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

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Chemical Property of 1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

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Technology Process of 1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

There total 5 articles about 1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1312572-63-6
1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid

: 1312572-64-7
1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1312572-64-7
1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 72 h / 20 °C

2.1: ethanol / 16 h / Reflux

3.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate / 3 h

4.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

5.2: 20 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride / N,N-dimethyl-formamide / 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; ammonium chloride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 675149-01-6
1-thiocarbamoyl-piperidine-4-carboxylic acid ethyl ester

: 1312572-64-7
1-[4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 16 h / Reflux

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethyl acetate / 3 h

3.1: toluene-4-sulfonic acid / 1,4-dioxane / 100 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C

4.2: 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium chloride / N,N-dimethyl-formamide / 1 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen; ammonium chloride; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;