N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

Base Information

Chemical Name:N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide
CAS No.:1342891-18-2
Molecular Formula:C₂₆H₂₆N₂O₄
Molecular Weight:430.503
Hs Code.:

Synonyms:N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

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Chemical Property of N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

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Technology Process of N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

There total 5 articles about N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1342891-17-1
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)aniline

: 3535-37-3
3,4-dimethoxybenzoic acid chloride

: 1342891-18-2
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm201018g

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1342891-18-2
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic anhydride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 °C

1.2: 0.5 h

2.1: xylene / 0.5 h / 130 °C / Microwave irradiation

3.1: n-butyllithium / tetrahydrofuran / 0.58 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: zinc(II) chloride / methanol / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 20 °C

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; xylene;

Reference yield:

: 1342891-40-0
2-bromo-5-((2-methylbut-3-yn-2-yl)oxy)pyridine

: 1342891-18-2
N-((2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl)-3,4-dimethoxy-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: xylene / 0.5 h / 130 °C / Microwave irradiation

2.1: n-butyllithium / tetrahydrofuran / 0.58 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: zinc(II) chloride / methanol / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 20 °C

With n-butyllithium; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; xylene;