4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride

Base Information

• Chemical Name: 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride
• CAS No.: 87692-13-5
• Molecular Formula: C₂₁H₂₂FN₃O₂*ClH
• Molecular Weight: 403.884
• Mol file: 87692-13-5.mol

Synonyms:4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride

Chemical Property of 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride

There total 6 articles about 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

4(1,2-benzisoxazol-3-yl)piperazine (87691-89-2) + 4-chloro-p-fluorobutyrophenone propylene ketal (4497-36-3) → 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride (87692-13-5)

Guidance literature:

Reference yield:

3-(4-{3-[2-(4-Fluoro-phenyl)-[1,3]dioxolan-2-yl]-propyl}-piperazin-1-yl)-benzo[d]isoxazole → 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride (87692-13-5)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.25h; Yield given; Heating;

DOI:10.1021/jm00153a010

Reference yield:

1,2-benz-4-isooxazolin-3-one (21725-69-9) → 4-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>-1-(4-fluorophenyl)-1-butanone hydrochloride (87692-13-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / POCl₃, Et₃N / 16 h / Heating

2: 24 h / 125 °C

3: K₂CO₃, KI / acetonitrile / 20 h / Heating

4: 3 N HCl / ethanol / 0.25 h / Heating

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; trichlorophosphate; In ethanol; acetonitrile;

DOI:10.1021/jm00153a010

upstream raw materials:

1,2-benz-4-isooxazolin-3-one

salicylhydroxamic acid

4(1,2-benzisoxazol-3-yl)piperazine

3-chlorobenzisoxazole

Downstream raw materials:

α-<3-<4-(1,2-benzisoxazol-3-yl)-1-piperazinyl>propyl>-4-fluorobenzenemethanol