C₆₁H₇₅N₅O₁₅Si

Base Information

• Chemical Name: C₆₁H₇₅N₅O₁₅Si
• CAS No.: 602301-47-3
• Molecular Formula: C₆₁H₇₅N₅O₁₅Si
• Molecular Weight: 1146.38
• Mol file: 602301-47-3.mol

Synonyms:C₆₁H₇₅N₅O₁₅Si

Chemical Property of C₆₁H₇₅N₅O₁₅Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₁H₇₅N₅O₁₅Si

There total 11 articles about C₆₁H₇₅N₅O₁₅Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-asparagine benzyl ester trifluoroacetate (105220-22-2) + 3-(3-{3-[5-benzyloxycarbonylamino-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl}-4-methoxymethoxy-phenyl)-2-[2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-pentanoylamino]-propionic acid → C61H75N5O15Si (602301-47-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1002/anie.200351130

Reference yield:

(2S,3S)-2-Hydroxy-3-methylpentanoic acid (488-15-3,59653-35-9,70748-47-9,86540-81-0,86630-77-5,51576-04-6) → C61H75N5O15Si (602301-47-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 56 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; N-methylmorpholine / dimethylformamide / 0 °C

2: 85 percent / K₂CO₃ / acetone

3: 88 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

4: 71 percent / Pd(dppf)Cl₂; KOAc / dimethylsulfoxide / 80 °C

5: 84 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 95 °C

6: aq. LiOH / tetrahydrofuran / 0 °C

7: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

DOI:10.1002/anie.200351130

Reference yield:

p-Anisaldehyde dimethyl acetal (2186-92-7) → C61H75N5O15Si (602301-47-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / TsOH / tetrahydrofuran

2: 84 percent / Pd(PPh₃)4; aq. Na₂CO₃ / 1,2-dimethoxy-ethane / 95 °C

3: aq. LiOH / tetrahydrofuran / 0 °C

4: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 0 °C

With lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.200351130

upstream raw materials:

L-asparagine benzyl ester trifluoroacetate

(2S,3S)-2-Hydroxy-3-methylpentanoic acid

p-Anisaldehyde dimethyl acetal

2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride

Downstream raw materials:

(S)-2-{(S)-3-(3-{(S)-3-[(2R,4R,5R)-5-Amino-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-3-hydroxy-2-oxo-2,3-dihydro-1H-indol-7-yl}-4-methoxymethoxy-phenyl)-2-[(2S,3S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-pentanoylamino]-propionylamino}-butaoic acid

TMC-95A