N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

Base Information

• Chemical Name: N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine
• CAS No.: 1086277-51-1
• Molecular Formula: C₄₁H₃₇F₂N₅O
• Molecular Weight: 653.774

Synonyms:N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

Chemical Property of N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

Chemical Property:

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Technology Process of N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

There total 1 articles about N₁-[3,3-bis(4-fluorophenyl)propanoyl]-N₂-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H14F2N2O + N-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine (1001159-95-0) → N1-[3,3-bis(4-fluorophenyl)propanoyl]-N2-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine (1086277-51-1)

Guidance literature:

N-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine; With sodium hydride; In mineral oil; at 50 ℃; for 0.5h; Inert atmosphere;

C₁₈H₁₄F₂N₂O; In mineral oil; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1021/jm800841w

Reference yield: 85.0%

N1-[3,3-bis(4-fluorophenyl)propanoyl]-N2-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine (1086277-51-1) + trifluoroacetic acid (76-05-1) → N1-[3,3-bis(4-fluorophenyl)propanoyl]-N2-[3-(1H-imidazol-4-yl)propyl]guanidine bis(trifluoroacetic acid)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/jm800841w

upstream raw materials:

N-[3-(1-trityl-1H-imidazol-4-yl)propyl]guanidine

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