methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Base Information

Chemical Name:methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate
CAS No.:613263-91-5
Molecular Formula:C₁₃H₁₆F₃NO₅S
Molecular Weight:355.335
Hs Code.:

Synonyms:methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

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Chemical Property of methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

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Technology Process of methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

There total 2 articles about methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 57746-16-4
(S)-methyl 2-(dimethylamino)-3-(4-hydroxyphenyl)propanoate

: 613263-91-5
methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.202005891

Reference yield:

: 1260499-43-1
methyl (S)-N,N-dimethyl-O-(tert-butyldimethylsilyl)tyrosinate

: 613263-91-5
methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.202005891

Reference yield:

: 141-75-3
butyryl chloride

: 613263-91-5
methyl (S)-2-(dimethylamino)-3-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)propanoate

: C₁₃H₁₆ClNO₃

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 16h; Sealed tube; Inert atmosphere;
DOI:10.1002/anie.202005891