1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Base Information

Chemical Name:1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone
CAS No.:866141-78-8
Molecular Formula:C₂₄H₂₅F₃N₄O
Molecular Weight:442.484
Hs Code.:

1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6<i>H</i>-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Synonyms:1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Suppliers and Price of 1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

There total 8 articles about 1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866141-77-7
2-trifluoromethyl-4-acetylphenylboronic acid pinacol ester

: 866141-75-5
(S)-6-cyclopropylmethyl-2-bromo-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraazaacenaphthylene

: 866141-78-8
1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Guidance literature:: With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 100 ℃;
DOI:10.1021/jm049085v

Reference yield:

: 268547-52-0,94220-37-8
5-methyl-1H-pyrazolo[4,3-b]pyridine-7-ol

: 866141-78-8
1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: 95 percent / phosphorus oxychloride / acetonitrile / 3 h / Heating

2.1: 98 percent / bromine / aq. methanol / 0.5 h

3.1: p-toluenesulfonic acid / 16 h / 150 °C

4.1: 9.8 g / aq. hydrobromic acid / 72 h / 120 °C

5.1: NaH / dimethylformamide / 0.25 h / 20 °C

5.2: 64 percent / dimethylformamide / 1 h / 20 °C

6.1: 3.78 g / aq. sodium carbonate; barium hydroxide; Pd(PPh₃)4 / toluene; ethanol / 100 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; trichlorophosphate; In methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; 6.1: Suzuki coupling;
DOI:10.1021/jm049085v

Reference yield:

: 94220-38-9
7-chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine

: 866141-78-8
1-[4-(6-cyclopropylmethyl-7-ethyl-4-methyl-7,8-dihydro-6H-1,3,6,8a-tetraaza-acenaphthylen-2-yl)-3-trifluoromethyl-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 98 percent / bromine / aq. methanol / 0.5 h

2.1: p-toluenesulfonic acid / 16 h / 150 °C

3.1: 9.8 g / aq. hydrobromic acid / 72 h / 120 °C

4.1: NaH / dimethylformamide / 0.25 h / 20 °C

4.2: 64 percent / dimethylformamide / 1 h / 20 °C

5.1: 3.78 g / aq. sodium carbonate; barium hydroxide; Pd(PPh₃)4 / toluene; ethanol / 100 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide; toluene; 5.1: Suzuki coupling;
DOI:10.1021/jm049085v