(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester
CAS No.:1448960-10-8
Molecular Formula:C₃₂H₄₅NO₅
Molecular Weight:523.713
Hs Code.:

Synonyms:(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

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Chemical Property of (±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

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Technology Process of (±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

There total 15 articles about (±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1448960-09-5
C₂₆H₄₀F₃NO₆S

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1448960-10-8
(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: 1448960-06-2
(±)-[6-(6-bromohexyl)-2,5,7,8-tetramethylchroman-2-yl]methanol

: 1448960-10-8
(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 6 h / 80 °C

2: hydrogen; palladium on activated charcoal / methanol

3: pyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With pyridine; sodium azide; palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.015

Reference yield:

: 1448960-07-3
(±)-[6-(6-azidohexyl)-2,5,7,8-tetramethylchroman-2-yl]methanol

: 1448960-10-8
(±)-{6-[2-(4-formylphenoxymethyl)-2,5,7,8-tetramethylchroman-6-yl]hexyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium on activated charcoal / methanol

2: pyridine / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; potassium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.06.015