6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Base Information

Chemical Name:6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]
CAS No.:784144-80-5
Molecular Formula:C₁₉H₁₄F₃NO₂
Molecular Weight:345.321
Hs Code.:

Synonyms:6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Suppliers and Price of 6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Chemical Property:

Purity/Quality:

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Technology Process of 6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

There total 3 articles about 6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 784144-76-9
2-(4-hydroxy-6-methyl-2-trifluoromethyl-4H-chromen-4-yl)-1-phenylethan-1-one oxime

: 784144-80-5
6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Guidance literature:: With hydrogenchloride; In ethanol;
DOI:10.1007/s11172-006-0288-x

Reference yield:

: 579-00-0
6-methyl-2-trifluoromethyl-chromen-4-one

: 784144-80-5
6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / diethyl ether / 0.67 h

1.2: 62 percent / diethyl ether; tetrahydrofuran / 2 h / 20 °C

2.1: 89 percent / HCl / ethanol

With hydrogenchloride; lithium diisopropyl amide; In diethyl ether; ethanol;
DOI:10.1007/s11172-006-0288-x

Reference yield:

: 10341-75-0
(E)-1-phenylethanone oxime

: 784144-80-5
6-methyl-3'-phenyl-2-trifluoromethylspiro[4H-chromene-4,5'-4',5'-dihydroisoxazole]

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / diethyl ether / 0.67 h

1.2: 62 percent / diethyl ether; tetrahydrofuran / 2 h / 20 °C

2.1: 89 percent / HCl / ethanol

With hydrogenchloride; lithium diisopropyl amide; In diethyl ether; ethanol;
DOI:10.1007/s11172-006-0288-x