[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate
CAS No.:1193706-34-1
Molecular Formula:C₁₇H₁₇FO₇S₂
Molecular Weight:416.448
Hs Code.:

Synonyms:[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

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Chemical Property of [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

There total 7 articles about [5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1193708-88-1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methanol

: 98-59-9
p-toluenesulfonyl chloride

: 1193706-34-1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 2105-94-4
4-bromo-2-fluorophenol

: 1193706-34-1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 3 h / 100 °C

2: aluminum (III) chloride / 3 h / 150 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1.83 h / 60 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 44 h / Reflux

5: potassium hydroxide / 1,4-dioxane; water / Alkaline aqueous solution

6: potassium carbonate; L-proline / copper(l) iodide / dimethyl sulfoxide / 2 h / 140 °C / Microwave irradiation

7: dmap; triethylamine / dichloromethane / 1 h / 20 °C

With pyridine; dmap; aluminum (III) chloride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; L-proline; potassium hydroxide; copper(l) iodide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Fries Rearrangement;

Reference yield:

: 1089706-28-4
1-(5-bromo-3-fluoro-2-hydroxyphenyl)ethan-1-one

: 1193706-34-1
[5-fluoro-7-(methylsulfonyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.83 h / 60 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 44 h / Reflux

3: potassium hydroxide / 1,4-dioxane; water / Alkaline aqueous solution

4: potassium carbonate; L-proline / copper(l) iodide / dimethyl sulfoxide / 2 h / 140 °C / Microwave irradiation

5: dmap; triethylamine / dichloromethane / 1 h / 20 °C

With dmap; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; L-proline; potassium hydroxide; copper(l) iodide; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;