(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Base Information

Chemical Name:(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate
CAS No.:1287261-31-7
Molecular Formula:C₃₀H₃₂N₂O₅
Molecular Weight:500.594
Hs Code.:

Synonyms:(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

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Chemical Property of (S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

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Technology Process of (S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

There total 7 articles about (S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1287261-34-0
C₂₁H₂₄N₂O₄

: 501-52-0
3-Phenylpropionic acid

: 1287261-31-7
(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: 3-Phenylpropionic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

C₂₁H₂₄N₂O₄; In tetrahydrofuran; for 8h;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-61-8
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-31-7
(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-38-9
(S)-tert-butyl 7-hydroxy-3-(phenethylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-31-7
(S)-methyl 2-(3-(phenethylcarbamoyl)-2-(3-phenylpropanoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: triethylamine; trifluoroacetic acid / dichloromethane

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

3.2: 8 h

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z