(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

Base Information

Chemical Name:(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide
CAS No.:1307233-53-9
Molecular Formula:BrH*C₂₂H₂₁N₇O₂
Molecular Weight:496.366
Hs Code.:

Synonyms:(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

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Chemical Property of (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

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Technology Process of (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

There total 8 articles about (4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1307233-44-8
(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 1307233-53-9
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

Guidance literature:: With hydrogen bromide; In methanol; dichloromethane; water;

Reference yield:

: 6320-39-4
3-aminopyridin-4-ol

: 1307233-53-9
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: N-Bromosuccinimide / acetic acid / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

5: hydrogen bromide / dichloromethane; water; methanol

With N-Bromosuccinimide; hexachloroethane; hydrogen bromide; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1307233-73-3
3-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-amine

: 1307233-53-9
(4-(5-Amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone hydrobromide

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetic acid / 20 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

3: hydrogen bromide / dichloromethane; water; methanol

With N-Bromosuccinimide; hydrogen bromide; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid;