methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

Base Information

Chemical Name:methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate
CAS No.:928850-27-5
Molecular Formula:C₂₆H₃₄N₄O₆
Molecular Weight:498.579
Hs Code.:

Synonyms:methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

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Chemical Property of methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

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Technology Process of methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

There total 4 articles about methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 68502-22-7
3-amino-4-benzylamine-benzoic acid methyl ester

: 322474-21-5,107819-90-9
1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea

: 928850-27-5
methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1016/j.bmc.2006.12.024

Reference yield:

: 3987-92-6
methyl 4-amino-3-nitrobenzoate

: 928850-27-5
methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 72 h / 70 °C

2: 4.9 g / hydrazine hydrate; aq. HCl / Pd/C / ethanol / 2 h / 20 °C

3: 62 percent / HgCl₂; triethylamine / dimethylformamide / 7 h / 20 °C

With hydrogenchloride; hydrazine hydrate; triethylamine; mercury dichloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.024

Reference yield:

: 68502-46-5
4-benzylamine-3-nitro-benzoic acid methyl ester

: 928850-27-5
methyl 4-(benzylamino)-3-[N',N''-bis(tert-butoxycarbonyl)guanidino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 4.9 g / hydrazine hydrate; aq. HCl / Pd/C / ethanol / 2 h / 20 °C

2: 62 percent / HgCl₂; triethylamine / dimethylformamide / 7 h / 20 °C

With hydrogenchloride; hydrazine hydrate; triethylamine; mercury dichloride; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.12.024