N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine
• CAS No.: 1443132-14-6
• Molecular Formula: C₃₁H₃₄N₂O₄
• Molecular Weight: 498.622
• Mol file: 1443132-14-6.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine

There total 2 articles about N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine (95753-56-3,324017-21-2) + cyclohexanecarbaldehyde (2043-61-0) → N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine (1443132-14-6)

Guidance literature:

4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine; cyclohexanecarbaldehyde; With acetic acid; In acetonitrile; at 20 ℃; for 2h;

With sodium tris(acetoxy)borohydride; In acetonitrile; at 20 ℃;

DOI:10.1021/jm4002988

Reference yield:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)(cyclohexylmethyl)amino)phenyl)propanoic acid (1443132-15-7) → N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine (1443132-14-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2015.11.006

Reference yield: 94.8%

di-tert-butyl dicarbonate (24424-99-5) + N-(9-fluorenylmethoxycarbonyl)-p-(N-cyclohexylmethylamino)-L-phenylalanine (1443132-14-6) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)(cyclohexylmethyl)amino)phenyl)propanoic acid (1443132-15-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 45 - 50 ℃; for 72h;

DOI:10.1021/jm4002988

upstream raw materials:

4-amino-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-phenylalanine

cyclohexanecarbaldehyde

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)(cyclohexylmethyl)amino)phenyl)propanoic acid

Downstream raw materials:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((tert-butoxycarbonyl)(cyclohexylmethyl)amino)phenyl)propanoic acid