(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

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Chemical Name:(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide
CAS No.:1313745-41-3
Molecular Formula:C₄₅H₄₀ClN₅O₇
Molecular Weight:798.295
Hs Code.:

(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

Synonyms:(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

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Chemical Property of (2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

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Technology Process of (2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

There total 3 articles about (2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179149-21-3
3-chloro-5-methoxyisoquinoline-1-carboxylic acid

: C₂₆H₂₈N₄O₃*2ClH

: 611-71-2
(R)-Mandelic Acid

: 1313745-41-3
(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 3h;

Reference yield:

: 56297-30-4
2,5-(4′-nitrophenyl)furan

: 1313745-41-3
(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / 20 % Pd(OH)2/C / ethyl acetate; methanol / 4 h / 760.05 Torr

2: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 16 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 4 h

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h

With hydrogenchloride; hydrogen; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; HATU; 20 % Pd(OH)2/C; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 53715-17-6
2,5-bis(4-aminophenyl)furan

: 1313745-41-3
(2S)-1-((3-chloro-5-methoxy-1-isoquinolinyl)carbonyl)-N-(4-(5-(4-((((2S)-1-((2R)-2-hydroxy-2-phenylacetyl)-2-pyrrolidinyl)carbonyl)amino)phenyl)-2-furyl)phenyl)-2-pyrrolidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline / dichloromethane / 16 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 4 h

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h

With hydrogenchloride; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;