3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

Base Information

Chemical Name:3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile
CAS No.:1607590-87-3
Molecular Formula:C₁₆H₁₆N₄O₂S
Molecular Weight:328.395
Hs Code.:

Synonyms:3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

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Chemical Property of 3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

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Technology Process of 3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

There total 7 articles about 3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607590-87-3
3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 1 h / 90 °C

With tetrabutylammonium nitrate; triethylamine; trichlorophosphate; In dichloromethane; isopropyl alcohol;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607590-86-2
3-(3-aminocyclohexyl)acrylonitrile hydrochloride

: 1607590-87-3
3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

Guidance literature:: With triethylamine; In isopropyl alcohol; at 90 ℃; for 1h;

Reference yield:

: 334932-13-7,218772-92-0,222530-33-8
3-[(tert-butoxycarbonyl)amino]cyclo-hexanecarboxylic acid

: 1607590-87-3
3-{3-[(6-nitrothieno[3,2-b]pyridin-7-yl)amino]cyclohexyl}acrylonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

1.2: 1 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C

3.2: 20 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

5.1: triethylamine / isopropyl alcohol / 1 h / 90 °C

With hydrogenchloride; potassium tert-butylate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; isopropyl alcohol;