N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine

Base Information

Chemical Name:N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine
CAS No.:122670-49-9
Molecular Formula:C₁₇H₁₃F₄NO₆
Molecular Weight:403.287
Hs Code.:
Mol file:122670-49-9.mol

Synonyms:2-Fmtng;N-{[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl}-N-(methoxycarbonyl)glycine;Glycine,N-[[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl);

Suppliers and Price of N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine

Chemical Property:

Vapor Pressure:2.22E-12mmHg at 25°C
Boiling Point:537.4°Cat760mmHg
Flash Point:278.8°C
PSA：93.14000
Density:1.484g/cm³
LogP:3.29950

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine

There total 10 articles about N-((2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl)carbonyl)-N-(methoxycarbonyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 122670-57-9
N-<<2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>carbonyl>-N-(methoxycarbonyl)glycine tert-butyl ester

: 122670-49-9
N-[[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl)glycine

Guidance literature:: With formic acid; In water; for 1.5h;
DOI:10.1021/jm00112a029

Reference yield:

: 85674-78-8
5-Methyl-2-methoxy-1-(trifluoromethyl)naphthalene

: 122670-49-9
N-[[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl)glycine

Guidance literature:: Multi-step reaction with 10 steps

1: 40 percent / fuming HNO₃, Ac₂O / 5 °C

2: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 1034.3 Torr

3: 62 percent / NaNO₂, HF, pyridine / 2 h / 65 °C

4: 100 percent / n-bromosuccinimide (NBS), (PhCO₂)2 / CCl₄ / 4 h / Heating

5: 99 percent / HCO₂Na / ethanol; H₂O / 2 h / Heating

6: 71 percent / Jones reagent / acetone / 2 h / 10 - 15 °C

7: COCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

8: 96 percent / Et₃N / tetrahydrofuran / 0.5 h / 0 - 20 °C

9: 1.) NaH / 1.) THF, 55-60 deg C, 45 min, 2.) THF, RT, 30 min

10: 98 percent / HCO₂H / H₂O / 1.5 h

With pyridine; N-Bromosuccinimide; formic acid; jones reagent; hydrogen fluoride; hydrogen; nitric acid; sodium formate; acetic anhydride; sodium hydride; triethylamine; sodium nitrite; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00112a029

Reference yield:

: 122670-70-6
2-methoxy-5-methyl-6-nitro-1-(trifluorormethyl)naphthalene

: 122670-49-9
N-[[2-fluoro-6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]carbonyl]-N-(methoxycarbonyl)glycine

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / 1034.3 Torr

2: 62 percent / NaNO₂, HF, pyridine / 2 h / 65 °C

3: 100 percent / n-bromosuccinimide (NBS), (PhCO₂)2 / CCl₄ / 4 h / Heating

4: 99 percent / HCO₂Na / ethanol; H₂O / 2 h / Heating

5: 71 percent / Jones reagent / acetone / 2 h / 10 - 15 °C

6: COCl₂ / dimethylformamide; CH₂Cl₂ / 1 h

7: 96 percent / Et₃N / tetrahydrofuran / 0.5 h / 0 - 20 °C

8: 1.) NaH / 1.) THF, 55-60 deg C, 45 min, 2.) THF, RT, 30 min

9: 98 percent / HCO₂H / H₂O / 1.5 h

With pyridine; N-Bromosuccinimide; formic acid; jones reagent; hydrogen fluoride; hydrogen; sodium formate; sodium hydride; triethylamine; sodium nitrite; dibenzoyl peroxide; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00112a029