3-(3-CHLORO-4-FLUORO-PHENYL)-PROPAN-1-OL

Base Information

• Chemical Name: 3-(3-CHLORO-4-FLUORO-PHENYL)-PROPAN-1-OL
• CAS No.: 1057671-53-0
• Molecular Formula: C₉H₁₀ClFO
• Molecular Weight: 188.629
• Mol file: 1057671-53-0.mol

Synonyms:3-(3-chloro-4-fluorophenyl)-1-propanol

Chemical Property of 3-(3-CHLORO-4-FLUORO-PHENYL)-PROPAN-1-OL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-CHLORO-4-FLUORO-PHENYL)-PROPAN-1-OL

There total 4 articles about 3-(3-CHLORO-4-FLUORO-PHENYL)-PROPAN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ethyl 3-(3-chloro-4-fluorophenyl)propanoate (1057674-91-5) → 3-(3-chloro-4-fluorophenyl)-1-propanol (1057671-53-0)

Guidance literature:

ethyl 3-(3-chloro-4-fluorophenyl)propanoate; With lithium aluminium tetrahydride; In diethyl ether; for 1h; Inert atmosphere; Cooling with ice;

With water; sodium hydroxide; In diethyl ether; at 20 ℃; for 0.5h;

Reference yield:

3-(3-chloro-4-fluorophenyl)-2-propyne-1-ol (220708-02-1) → 3-(3-chloro-4-fluorophenyl)-1-propanol (1057671-53-0)

Guidance literature:

With hydrogen; Wilkinson's catalyst; In toluene; at 65 ℃; for 10h;

Reference yield:

3-Chloro-4-fluorobenzaldehyde (34328-61-5) → 3-(3-chloro-4-fluorophenyl)-1-propanol (1057671-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: copper(l) chloride; sodium tetrahydroborate; methanol / 0.5 h / Inert atmosphere; Cooling with ice

3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / Inert atmosphere; Cooling with ice

3.2: 0.5 h / 20 °C

With methanol; sodium tetrahydroborate; lithium aluminium tetrahydride; copper(l) chloride; In tetrahydrofuran; diethyl ether;

upstream raw materials:

3-(3-chloro-4-fluorophenyl)-2-propyne-1-ol

3-Chloro-4-fluorobenzaldehyde

ethyl (2E)-3-(3-chloro-4-fluorophenyl)acrylate

ethyl 3-(3-chloro-4-fluorophenyl)propanoate

Downstream raw materials:

1-(3-bromopropyl)-3-chloro-4-fluorobenzene

Refernces

• 1、 -. "AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF". Page/Page column 131. . Retrieved 2010/04/25.