C₂₀H₄₂O₃Si

Base Information

• Chemical Name: C₂₀H₄₂O₃Si
• CAS No.: 1549824-63-6
• Molecular Formula: C₂₀H₄₂O₃Si
• Molecular Weight: 358.637
• Mol file: 1549824-63-6.mol

Synonyms:C₂₀H₄₂O₃Si

Chemical Property of C₂₀H₄₂O₃Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₄₂O₃Si

There total 11 articles about C₂₀H₄₂O₃Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,2S,3S,4S)-phenyl-2-(2-ethoxy-2-oxoethyl)-1,3-dimethyl-4-(triisopropylsilyloxy)cyclohexanecarboxylate (1549824-53-4) → C20H42O3Si (1549824-63-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.12.110

Reference yield:

(2R,3S)-6-iodo-2-methyl-3-(triisopropylsilyloxy)hept-6-enal (1549824-31-8) → C20H42O3Si (1549824-63-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 50 °C

3.1: L-Selectride / toluene / 2 h / -78 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; L-Selectride; sodium hydride; triethylamine; In tetrahydrofuran; toluene; mineral oil; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.tetlet.2013.12.110

Reference yield:

(2R,3S)-methyl 6-iodo-2-methyl-3-(triisopropylsilyloxy)hept-6-enoate (1549824-21-6) → C20H42O3Si (1549824-63-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 2 h / -78 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 4 h / 50 °C

4.1: L-Selectride / toluene / 2 h / -78 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; L-Selectride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;

DOI:10.1016/j.tetlet.2013.12.110

upstream raw materials:

(2R,3S)-methyl 6-iodo-2-methyl-3-(triisopropylsilyloxy)hept-6-enoate

C₉H₁₅IO₃

(2R,3S)-6-iodo-2-methyl-3-(triisopropylsilyloxy)hept-6-enal

(4S,5S,E)-ethyl 8-iodo-4-methyl-5-(triisopropylsilyloxy)nona-2,8-dienoate

Downstream raw materials:

(1S,2S,3S,4S)-3-(2-hydroxyethyl)-4-(hydroxymethyl)-2,4-dimethylcyclohexanol