(Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle

Base Information

• Chemical Name: (Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle
• CAS No.: 119099-63-7
• Molecular Formula: C₁₅H₁₉NO₄S
• Molecular Weight: 309.386
• Mol file: 119099-63-7.mol

Synonyms:(Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle

Chemical Property of (Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle

There total 1 articles about (Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(chlorosulfanyl)morpholine (2958-89-6) + methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) → (Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle (119099-63-7)

Guidance literature:

With triethylamine; In diethyl ether; at -78 - 20 ℃;

DOI:10.1016/0040-4039(88)85134-7

Reference yield: 92.0%

(Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle (119099-63-7) → (Z)-3-phenyl-2-(sulfinomethyl)prop-2-enoate de methyle (119099-79-5)

Guidance literature:

With methanesulfonic acid; water; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/0040-4039(88)85135-9

Reference yield:

(Z)-4-<(morpholin-4-ylsulfinyl)methyl>-3-phenylprop-2-enoate de methyle (119099-63-7) → 2-<(methylsulfonyl)methyl>-3-phenylprop-2-enoate de methyle

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 3 equiv water, 1 equiv methanesulfonic acid / tetrahydrofuran / 2 h / 0 °C

2: 74 percent / potassium carbonate / tetrahydrofuran; dimethylformamide

With methanesulfonic acid; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(88)85135-9

upstream raw materials:

N-(chlorosulfanyl)morpholine

methyl 3-hydroxy-2-methylidene-3-phenylpropionate

Downstream raw materials:

(Z)-3-phenyl-2-(sulfinomethyl)prop-2-enoate de methyle