2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

Base Information

Chemical Name:2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine
CAS No.:865787-13-9
Molecular Formula:C₂₀H₂₄N₄S
Molecular Weight:352.503
Hs Code.:

2-[2-(4-benzo[<i>d</i>]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

Synonyms:2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

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Chemical Property of 2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

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Technology Process of 2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

There total 4 articles about 2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 865787-07-1
3-{4-[2-(4-methyl-2-nitro-phenyl)-ethyl]-piperazin-1-yl}-benzo[d]isothiazole

: 865787-13-9
2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

Guidance literature:: With hydrogen; triethylamine; nickel;
DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

: 865787-01-5
1-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-2-(4-methyl-2-nitro-phenyl)-ethanone

: 865787-13-9
2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 49 percent / BH₃*SMe₂ / toluene / Heating

2: 66 percent / H₂; Et₃N / Raney Ni

With dimethylsulfide borane complex; hydrogen; triethylamine; nickel; In toluene;
DOI:10.1016/j.bmcl.2005.06.097

Reference yield:

: 622-47-9
4-tolylacetic acid

: 865787-13-9
2-[2-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-5-methyl-phenylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / TFAA; NH₄NO₃ / CHCl₃

2: 50 percent / BOP-Cl; Et₃N / CH₂Cl₂

3: 49 percent / BH₃*SMe₂ / toluene / Heating

4: 66 percent / H₂; Et₃N / Raney Ni

With ammonium nitrate; dimethylsulfide borane complex; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; trifluoroacetic anhydride; nickel; In dichloromethane; chloroform; toluene;
DOI:10.1016/j.bmcl.2005.06.097