2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

Base Information

Chemical Name:2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester
CAS No.:168965-45-5
Molecular Formula:C₂₆H₄₀N₂O₆
Molecular Weight:476.613
Hs Code.:

Synonyms:2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

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Chemical Property of 2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

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Technology Process of 2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

There total 9 articles about 2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 623-27-8
terephthalaldehyde,

: 168965-45-5
2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 25.2 g / H₂ / 10percent Pd/C / ethanol; H₂O / 3 h / 760 Torr / Ambient temperature

2: 82 percent / 48percent aq. HBr / toluene / 2 h / Heating

3: 74 percent / KNO₃, H₂SO₄ / 4 h / Ambient temperature

4: 98 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, 0 deg C, 90 min, 2.) THF, a) -78 deg C, 90 min, b) 0 deg C, 2 h

6: HCl, AcOH / 9 h / Heating

7: SOCl₂ / 6 h / Ambient temperature

8: CH₂Cl₂ / 36 h / Ambient temperature

With hydrogenchloride; n-butyllithium; thionyl chloride; sulfuric acid; hydrogen bromide; hydrogen; sodium hydride; acetic acid; potassium nitrate; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja953578v

Reference yield:

: 168965-43-3
ethyl 2-(acetylamino)-2-(ethoxycarbonyl)-3-(4-formyl-2-nitrophenyl)propanoate

: 168965-45-5
2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, 0 deg C, 90 min, 2.) THF, a) -78 deg C, 90 min, b) 0 deg C, 2 h

2: HCl, AcOH / 9 h / Heating

3: SOCl₂ / 6 h / Ambient temperature

4: CH₂Cl₂ / 36 h / Ambient temperature

With hydrogenchloride; n-butyllithium; thionyl chloride; acetic acid; In dichloromethane;
DOI:10.1021/ja953578v

Reference yield:

: 155526-65-1
4-(bromomethyl)-3-nitrobenzaldehyde

: 168965-45-5
2-tert-Butoxycarbonylamino-3-[4-((E)-dec-1-enyl)-2-nitro-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / NaH / dimethylformamide / 2.5 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, 0 deg C, 90 min, 2.) THF, a) -78 deg C, 90 min, b) 0 deg C, 2 h

3: HCl, AcOH / 9 h / Heating

4: SOCl₂ / 6 h / Ambient temperature

5: CH₂Cl₂ / 36 h / Ambient temperature

With hydrogenchloride; n-butyllithium; thionyl chloride; sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja953578v