2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1025804-60-7
Molecular Formula:C₂₉H₃₆N₄O₄S
Molecular Weight:536.695
Hs Code.:

Synonyms:2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

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Technology Process of 2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

There total 9 articles about 2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 110-78-1
Propyl isocyanate

: 164412-97-9
ethyl 1-<<2'-(aminocarbonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

: 1025804-60-7
2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In 1,2-dimethoxyethane;
DOI:10.1021/jm00013a013

Reference yield:

: 638-29-9
n-valeryl chloride

: 1025804-60-7
2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / pyridine / CH₂Cl₂ / 0 °C

2: 87 percent / triethylamine / ethanol / 50 h / 0 °C

3: 72 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

4: 68 percent / K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 85 percent / CF₃COOH / CH₂Cl₂ / 6 h / Ambient temperature

6: thionyl chloride / 4 h / Heating

7: 22percent NH₄OH / dioxane / 0.5 h / Ambient temperature

8: 50 percent / K₂CO₃ / 1,2-dimethoxy-ethane

With pyridine; dmap; ammonium hydroxide; thionyl chloride; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013

Reference yield:

: 139742-83-9
ethyl 2-cyano-2-n-butylcarbonylaminoacetate

: 1025804-60-7
2-Butyl-5-methylsulfanyl-3-[2'-(3-propyl-ureidocarbonyl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / triethylamine / ethanol / 50 h / 0 °C

2: 72 percent / PCl₅, 4-(dimethylamino)pyridine / CH₂Cl₂ / 12 h / Ambient temperature

3: 68 percent / K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 85 percent / CF₃COOH / CH₂Cl₂ / 6 h / Ambient temperature

5: thionyl chloride / 4 h / Heating

6: 22percent NH₄OH / dioxane / 0.5 h / Ambient temperature

7: 50 percent / K₂CO₃ / 1,2-dimethoxy-ethane

With dmap; ammonium hydroxide; thionyl chloride; phosphorus pentachloride; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00013a013