Technology Process of cis-/trans-1,3-Bis(mercaptomethyl)cyclohexane
There total 4 articles about cis-/trans-1,3-Bis(mercaptomethyl)cyclohexane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium sulfide; sulfuric acid;
In
N,N-dimethyl-formamide;
at 70 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82.1 percent / H2; (Bu)4N*HSO4 / (norbornadieneRhCl)2 / aq. phosphate buffer; cyclohexane / 24 h / 60 °C / 2585.74 Torr / pH 7.4
2: 90.2 percent / LiAlH4; AlCl3 / diethyl ether / 2 h / 20 °C
3: 77.5 percent / pyridine / 18 h
4: 54.8 percent / Na2S*9H2O; H2SO4 / dimethylformamide / 3 h / 70 °C
With
pyridine; sodium sulfide; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen; tetra(n-butyl)ammonium hydrogensulfate;
di-μ-chlorobis(norbornadiene)dirhodium(I);
In
phosphate buffer; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
1: Catalytic hydrogenation / 2: Reduction / 3: Tosylation / 4: Substitution;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90.2 percent / LiAlH4; AlCl3 / diethyl ether / 2 h / 20 °C
2: 77.5 percent / pyridine / 18 h
3: 54.8 percent / Na2S*9H2O; H2SO4 / dimethylformamide / 3 h / 70 °C
With
pyridine; sodium sulfide; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid;
In
diethyl ether; N,N-dimethyl-formamide;
1: Reduction / 2: Tosylation / 3: Substitution;
