Technology Process of α-{(1S,3R,4S,6S,8R,9R,10R)-6-methyl-13-oxo-10-azatetracyclo[7.2.2.03,8.04,10]tridecan-12-yl}methyl malonic acid benzyl methyl ester
There total 21 articles about α-{(1S,3R,4S,6S,8R,9R,10R)-6-methyl-13-oxo-10-azatetracyclo[7.2.2.03,8.04,10]tridecan-12-yl}methyl malonic acid benzyl methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1021/ja312065m
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: methanol; ethyl acetate / Inert atmosphere
2.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane; water; isopropyl alcohol / 3 h / 0 - 20 °C
3.1: pyridine / 2 h / Reflux
4.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 °C
4.2: 2 h / -78 °C
5.1: hydrogenchloride / acetone; water / 50 °C
6.1: sodium hydride / tetrahydrofuran / 20 °C
With
hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; tert.-butyl lithium; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; isopropyl alcohol; acetone; pentane;
DOI:10.1021/ja312065m
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / dichloromethane; water; isopropyl alcohol / 3 h / 0 - 20 °C
2.1: pyridine / 2 h / Reflux
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.42 h / -78 °C
3.2: 1 h / -78 °C
4.1: hydrogenchloride / water; 1,4-dioxane / 60 °C
5.1: sodium hydride / tetrahydrofuran / 20 °C
With
hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; tert.-butyl lithium; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; water; isopropyl alcohol; pentane;
DOI:10.1021/ja312065m
![(1S,3R,4S,6R,8R,9R)-6-methyl-12-methylene-10-azatetracyclo[7.2.2.0<sup>3,8</sup>.0<sup>4,10</sup>]tridecan-13-one](/Databaselist/images/loading.webp)
