N-BOC-3-AMINOPHENOL 97

Base Information

• Chemical Name: N-BOC-3-AMINOPHENOL 97
• CAS No.: 13683-93-7
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Hs Code.: 2924299090
• Mol file: 13683-93-7.mol

Synonyms:butyl 3-hydroxycarbanilate;

Chemical Property of N-BOC-3-AMINOPHENOL 97

Chemical Property:

• Vapor Pressure: 0.000677mmHg at 25°C
• Melting Point: 134-138?°C(lit.)
• Boiling Point: 299.3°Cat760mmHg
• Flash Point: 134.8°C
• PSA: 58.56000
• Density: 1.183g/cm³
• LogP: 2.81380

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-BOC-3-AMINOPHENOL 97

There total 1 articles about N-BOC-3-AMINOPHENOL 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

carbonochloridic acid, butyl ester (592-34-7) + m-Hydroxyaniline (591-27-5) → butyl 3-hydroxycarbanilate (13683-93-7)

Guidance literature:

In diethyl ether; for 1h;

DOI:10.1016/0223-5234(91)90127-9

Reference yield: 71.0%

butyl 3-hydroxycarbanilate (13683-93-7) + 3,4-dichlorophenylisocyanate (102-36-3) → O-3-[(butoxycarbonyl)amino]phenyl-N-(3,4-dichlorophenyl)carbamate

Guidance literature:

With triethylamine; In benzene; for 0.5h; Reflux;

DOI:10.1016/j.bioorg.2018.03.012

Reference yield: 67.0%

butyl 3-hydroxycarbanilate (13683-93-7) + 4-Methoxyphenyl isocyanate (5416-93-3) → O-3-[(butoxycarbonyl)amino]phenyl-N-(4-methoxyphenyl)carbamate

Guidance literature:

With triethylamine; In benzene; for 0.5h; Reflux;

DOI:10.1016/j.bioorg.2018.03.012

upstream raw materials:

carbonochloridic acid, butyl ester

m-Hydroxyaniline

Downstream raw materials:

butyl 3-(2,3-epoxypropoxy)carbanilate

[3-(3-tert-Butylamino-2-hydroxy-propoxy)-phenyl]-carbamic acid butyl ester

3-<2-hydroxy-3-(isopropylamino)propoxyl>carbanylic acid butyl ester

C₁₈H₁₉ClN₂O₄

Refernces

• 1、 Kettmann,Csollei,Racanska,Svec. "Synthesis and structure-activity relationships of new β-adrenoreceptor antagonists. Evidence for the electrostatic requirements for β-adrenoreceptor antagonists". . p. 843 - 851. Retrieved 2007/10/02.